What is Resveratrol?
Resveratrol was first isolated in 1940 from the roots of hellebore. In 1963, it was then isolated from the roots of Polygonum Cuspidatum, a traditional Chinese and Japanese medicinal plant. Resveratrol did not attract interest until 1992, when it was considered to explain some of the life long consumption cardio protective benefits of red wine. Since then, there have been many research reports that have shown Resveratrol can prevent or slow down a wide variety of illnesses from Cancer and Alzheimer’s to cardiovascular disease.
Resveratrol for cancer.
In 1997, Jang published a research paper reporting that
resveratrol inhibits carcinogenesis at multiple stages. They found that
topical application of resveratrol reduced the number of skin tumors in mice
by up to 98%. This triggered resveratrol research around the world.
Resveratrol (3,4’,5-trihydroxystilbene) belongs to a class of polyphenolic compounds called stilbenes. Some types of plants produce Resveratrol and other stilbenes in response to stress, injury, fungal infection, and ultraviolet (UV) radiation. It is found in the skins of certain red grapes, in peanuts, blueberries, some pines (Scots pine, eastern white pine) and the roots and stalks of Japanese knotweed (hu zhang in China) and giant knotweed.
Although a chemically produced version called Trans-Resveratrol was declared an Investigational New Drug by the National Institutes of Health in January of 2001, resveratrol did not gain large notoriety among the general public until a study released by Harvard Medical School in November 2006. In this study, researchers David Sinclair and Rafael de Cabo, Ph.D., determined that resveratrol increased the lifespan of obese mice and reversed nearly all of the changes in gene expression patterns found in mice on high calorie diets—some of which are associated with diabetes, heart disease, and other significant diseases related to obesity.
Update: As of mid 2007, Dr. David Sinclair is part of a group testing a Resveratrol formulation on humans with doses of 2500mg and 5000mg a day, and has recently finished phase "Ia" safety tests, and is further testing Resveratrol for specific positive results on various diseases.
What are the benefits of Resveratrol?
On non human mammals, it has been shown to prevent and shrink cancer, has been shown to have strong antiviral anti-fungal properties. RevGenetics has seen studies that have also shown neuro-protective, anti-aging, anti-inflammatory and life-prolonging effects on subjects*.
Resveratrol and Angiogenesis.
Angiogenesis is required for most cancer tumors to grow beyond a 2-3 mm
diameter. When delivered systemically, at a dose of 2.5-100mg per kg of body
weight, resveratrol has been found to inhibit the tumor activated
neovascularization and wound healing. The suppression by resveratrol could
have a role in its effect on stopping tumor growth.
In resveratrol obtained from dietary foods, such as red wine, their was some
evidence of therapeutic effects. At higher doses that can be achieved
through supplement concentrations and pharmacological sources, the
protective effects and results were more dramatic. In one study, a dose of
40 mg per kg of body weight increased the survival of mice from 0% to 70%
that had subcutaneous neuroblastomas.
Resveratrol and drug metabolism.
In studies using livers of resveratrol treated rats, it has been found that
it may prevent carcinogens while at the same time increasing the body's
capacity to eliminate harmful molecules.
Resveratrol as Antioxidant.
Reactive oxygen species are shown to have a damaging role to DNA as well as
other macromolecules. Resveratrol has a antioxidant capacity that can also
be related to the chemo preventative effects it has shown. Resveratrol
appears to prevent LDL oxidation in some studies. In stroke prone rats,
resveratrol significantly reduced oxidative stress markers.
Resveratrol and cholesterol
In 1982 resveratrol was shown to inhibit the deposit of triglycerides and
cholesterol in rat livers. Current studies are not conclusive.
Resveratrol and postmenopausal women
Resveratrol has been reported to act as a phytooestrogen in some systems. It
has been suggested that it has helped the effects of it Cardioprotective
effects. At this time the oestrogenic effects have been subjects of debate
and research is working to see if there is a firm connection for the
cardioprotective effects.
Resveratrol and immunity
resveratrol has been shown to reduce and suppress many types of
inflammation, which is a main interest in arthritis, psoriasis, and crohn's
disease. Inflammation can also play a part in cardiovascular disease and
cancer. Resveratrol could represent a positive alternative to current
treatments for chronic inflammation as aspirin taken for long period can
damage the lining of the stomach, while resveratrol does not. In addition,
resveratrol enhances immune response in mice, as well as shown to protect
them from infection by herpes simplex virus 1 and 2. This suggests
resveratrol interaction with the immune system is more complex, and that the
immune system could even be enhanced.
Other Resveratrol studies.
Resveratrol has been reported to protect against hearing loss, act as an
analgesic, reduce injury to spinal cord, liver, kidneys, lungs, intestine,
and colon. The results indicate that Resveratrol is not limited to help
against brain and heart injuries.
Studies we would like to see:
Because no comprehensive studies have been done for children regarding its effects on natural development, we do not recommend anyone under 18 take resveratrol at this time.
How does Resveratrol make one live longer?
David Sinclair of the Harvard Medical School found that it increases an enzyme called SIRT1 in a subject, it 'resets' proteins that limit the cells longevity. RevGenetics believes that by increasing these enzymes, we can theoretically increase the lifespan of the cells. In theory this could increase the human lifespan dramatically*. In one study it increased the lifespan of fish by 60%.
How much Resveratrol should I take?
Several Clinical Trials are currently underway for oral resveratrol in humans at dosages from 2.5 grams to 7.5 grams a day, including National Cancer Institute sponsored studies at the University of Michigan, USA, and the University of Lericester, in the UK, and some private corporations looking to produce similar drugs.
David Sinclair of the Harvard Medical School used it on non-human subjects. The dosage he used on the non-human subjects of his study, is equivalent to about 500mg for each 50lbs of a person's weight. Although this target was optimum in the Harvard study, many folks can take less on a daily basis as studies haven't concluded what the correct dosage would be.
In a recent update we received in June of 2007, we have been notified that David Sinclair has finished phase "Ia" safety tests using a Resveratrol formulation of 2500mg and 5000mg on humans, and is further testing Resveratrol for specific positive results on various diseases.
In January 2008, David Sinclair finished the first Human study of resveratrol specifically for diabetes. The formula used was a Resveratrol formulation and not the drug that is being creating for 2012, using the current Resveratrol discoveries.
At this time RevGenetics will provide you with 500mg and 300mg capsules so you can decide if you would like to use the Harvard dosage used and take 500mg for every 50lbs you have, or if you would like to take less on a daily basis to try Resveratrol as part of your nutritional regimen.
Why should I buy Resveratrol from RevGenetics?
RevGenetics was the first to offer R500 and now X1000, and only offers the best scientifically tested Resveratrol for you. It is HPLC tested. You are also provided the best price per milligram of Resveratrol, and get the largest dosage capsule of Resveratrol available to help you match the dosage in the Harvard studies. RevGenetics simply offers the best product, at the best price, for your daily needs. No one else offers a 1000mg capsule of Resveratrol. Beware of capsules that may say 500mg or less of grape extract but only provide a tiny percentage of Resveratrol. RevGenetics simply recommends 250mg of pure Resveratrol or more in each capsule. If you decide not to purchase from RevGenetics, we ask that you please search for this minimum quantity for your next purchase.
As a natural herbal supplement *these statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. Please refer to the scientific studies for detailed information of the possible benefits of RevGenetics Resveratrol.