Resveratrol Supplements - 500mg Each Resveratrol Capsule = 250 Bottles of Wine.
Resveratrol 99% Powder - Each 500mg capsule contains 495mg Trans-Resveratrol. The Resveratrol in this product comes from the Polygonum Cuspidatum plant.
Recommended Dosage:
1 or more capsules a day, but no more than one capsule per 50lbs of personal weight per day.
Why a 500mg Capsule?
Because 100mg is fine for mice, but it is simply too low for humans:
About
70% of the resveratrol dose given orally as a pill is absorbed;
nevertheless, oral bioavailability of resveratrol is low because it is
rapidly metabolized in intestines and liver into conjugated forms:
glucuronate and sulfonate.[1] Only trace amounts (below 5 ng/mL) of
unchanged resveratrol could be detected in the blood after 25 mg oral
dose.[1] Even when a very large dose of regular resveratrol (2.5 and 5
g) was given as uncoated pill, the concentration of resveratrol in
blood was only 2.4umol/L.[2]
[1]."High absorption but very low bioavailability of oral resveratrol in humans". Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004).
[2]. "Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent". David J. Boocock, et al (2007).
What about the stability of Resveratrol?
Resveratrol
has been found to be stable. The trans- form can undergo isomerisation
to the cis- form when exposed to ultraviolet irradiation.[3]
Trans-resveratrol in the powder form was found to be stable under
"accelerated stability" conditions of 75% humidity and 40 degrees C in
the presence of air.[4] Resveratrol content also stayed stable in the
skins of grapes and pomace taken after fermentation and stored for a
long period.[5]
[3].
"Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomers
in Spanish Red Vitis vinifera Wines". Lamuela-Raventos, RM (1995).
[4]. "Resveratrol and its glycon piceid are stable polyphenols". Prokop J, Abrman P, Seligson AL, Sovak M (2006).
[5]. "Stability of resveratrol over time and in the various stages of grape transformation". Bertelli AA, Gozzini A, Stradi R, Stella S, Bertelli A (1998).
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Features:
All natural herbal extract from plant root.
We only use vegetarian capsules.
The oxygen in all bottles have been reduced to 0.02% or less, to eliminate oxidation.
Herbal powder is independently tested in a United States laboratory for safety and purity.
Herbal powder has been independently verified to activate the SIRT1 Gene as good as, or better than research grade Resveratrol.
Made in the USA
Technical Specs:
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Extended Information:
The Resveratrol in this product comes from the natural polygonum cuspidatum plant root. The plant root is cleaned and made into powder. The powder then goes through an extraction process using alcohol and water. The extract from the process contains concentrated phytonutrients. This polygonum powder extract is then tested specifically for Trans-Resveratrol content to assure us of the amount of Trans-Resveratrol it contains. The powder is verified a second time using HPLC scientific lab equipment at the American Analytical Chemistry Labs in Illinois, for safety and purity.
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