Resveratrol Supplements - 500mg
(Capsules Starting at $66)
Each Resveratrol Capsule = 250 Bottles of Wine.
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Features:
Discounts available for non-recurring purchases when purchasing multiple bottles (4, 8, or 13). Monthly recurring purchases with lower price and free shipping are limited to 2 per customer.
Each Resveratrol Capsule = 250 Bottles of Wine.
Resveratrol 99% Powder - Each 500mg capsule contains 495mg Trans-Resveratrol. The Resveratrol in this product comes from the Polygonum Cuspidatum plant.
Recommended Dosage:
1 or more capsules a day, but no more than one capsule per 50lbs of personal weight per day.
The following mentions research done in animals and in labs. We do not claim our products will act in a similar
fashion in regular people. As a dietary supplement company, we only present the information for your
consideration.
Why a 500mg Capsule?
Because 100mg is fine for mice, but it is simply too low for humans:
About
70% of the resveratrol dose given orally as a pill is absorbed;
nevertheless, oral bioavailability of resveratrol is low because it is
rapidly metabolized in intestines and liver into conjugated forms:
glucuronate and sulfonate.[1] Only trace amounts (below 5 ng/mL) of
unchanged resveratrol could be detected in the blood after 25 mg oral
dose.[1] Even when a very large dose of regular resveratrol (2.5 and 5
g) was given as uncoated pill, the concentration of resveratrol in
blood was only 2.4umol/L.[2]
[1]."High absorption but very low bioavailability of oral resveratrol in humans". Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004).
[2]. "Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent". David J. Boocock, et al (2007).
What about the stability of Resveratrol?
Resveratrol
has been found to be stable. The trans- form can undergo isomerisation
to the cis- form when exposed to ultraviolet irradiation.[3]
Trans-resveratrol in the powder form was found to be stable under
"accelerated stability" conditions of 75% humidity and 40 degrees C in
the presence of air.[4] Resveratrol content also stayed stable in the
skins of grapes and pomace taken after fermentation and stored for a
long period.[5]
[3].
"Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomers
in Spanish Red Vitis vinifera Wines". Lamuela-Raventos, RM (1995).
[4]. "Resveratrol and its glycon piceid are stable polyphenols". Prokop J, Abrman P, Seligson AL, Sovak M (2006).
[5]. "Stability of resveratrol over time and in the various stages of grape transformation". Bertelli AA, Gozzini A, Stradi R, Stella S, Bertelli A (1998).
Does It Work ?
Resveratrol is one of 3 supplements we are working on for longevity. Resveratrol is aimed at the
P53 gene along with many other benefits. Astral Fruit is
specifically aimed at the Telomerase gene. A third supplement that we
have not yet made available is aimed at the P16 gene. We believe
maintaining these 3 genes in a healthy state will allow a person to
naturally live healthier for a longer period of time.
We
have looked through the literature, and there have only been small human
studies regarding resveratrol. There are no clinical studies regarding longevity in humans,
as it may take 20 years or more to produce a longevity study. The only
thing we can do is discuss current animal studies, and see how they may or may not relate to humans. Because of all the positive information from hundreds of studies in animals and in lab cells, it is believed that this maybe one of the most complex and beneficial herbal supplements available.
Are there any cautions I should be aware of?
In studies, resveratrol is suggested to be a weak inhibitor of
the P450 3A4 liver metabolism system, which is of unknown significance
for humans. Taking large amounts of resveratrol may increase blood
levels of drugs that are usually metabolized by CYP3A4. This simply
means that calcium channel blockers, statins, some immunosuppressant
drugs (like cyclosporine), and erectile dysfunction drugs such as
sildenafil, may have increased blood levels. Please be cautious when
taking resveratrol with anticoagulants or anti platelet drugs such as
Plavix(r) (Clopidogrel). An
increase in adenosine availability is involved in resveratrol
cardioprotection in rats. It maybe possible that an increase in adenosine can
increase uric acid temporarily. As a caution, it is not recommended long term for
people with a genetic predisposition to Gout.
We also advise the following:
* Keep out of reach and do not give to children.
* Do not exceed suggested maximum dose unless your doctor recommends it.
* If you have a bad reaction to the supplement discontinue use immediately.
* When undergoing treatment for any medical condition, are pregnant
(or lactating) please inform your physician when using any nutritional
supplements.
All natural herbal extract from plant root.
We only use vegetarian capsules.
The oxygen in all bottles have been reduced to 0.02% or less, to eliminate oxidation.
Herbal powder is independently tested in a United States laboratory for safety and purity.
Herbal powder has been independently verified to activate the SIRT1 Gene as good as, or better than research grade Resveratrol.
Made in the USA
Technical Specs:
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Extended Information:
The Resveratrol in this product comes from the natural polygonum cuspidatum plant root. The plant root is cleaned and made into powder. The powder then goes through an extraction process using alcohol and water. The extract from the process contains concentrated phytonutrients. This polygonum powder extract is then tested specifically for Trans-Resveratrol content to assure us of the amount of Trans-Resveratrol it contains. The powder is verified a second time using HPLC scientific lab equipment at the American Analytical Chemistry Labs in Illinois, for safety and purity.
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