Resveratrol Supplements - 1000mg Each Resveratrol Capsule = 500 Bottles of Wine.
Resveratrol 99% Powder - Each 1000mg capsule contains 990mg Trans-Resveratrol. The Resveratrol in this product comes from the Polygonum Cuspidatum plant.
Recommended Dosage:
1 or more capsules a day, but no more than one capsule per 100lbs of personal weight per day.
Why a 1000mg Capsule?
Because 100mg is fine for mice, but it is simply too low for humans:
About
70% of the resveratrol dose given orally as a pill is absorbed;
nevertheless, oral bioavailability of resveratrol is low because it is
rapidly metabolized in intestines and liver into conjugated forms:
glucuronate and sulfonate.[1] Only trace amounts (below 5 ng/mL) of
unchanged resveratrol could be detected in the blood after 25 mg oral
dose.[1] Even when a very large dose of regular resveratrol (2.5 and 5
g) was given as uncoated pill, the concentration of resveratrol in
blood was only 2.4umol/L.[2]
[1]."High absorption but very low bioavailability of oral resveratrol in humans". Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004).
[2]. "Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent". David J. Boocock, et al (2007).
What about the stability of Resveratrol?
Resveratrol
has been found to be stable. The trans- form can undergo isomerisation
to the cis- form when exposed to ultraviolet irradiation.[3]
Trans-resveratrol in the powder form was found to be stable under
"accelerated stability" conditions of 75% humidity and 40 degrees C in
the presence of air.[4] Resveratrol content also stayed stable in the
skins of grapes and pomace taken after fermentation and stored for a
long period.[5]
[3].
"Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomers
in Spanish Red Vitis vinifera Wines". Lamuela-Raventos, RM (1995).
[4]. "Resveratrol and its glycon piceid are stable polyphenols". Prokop J, Abrman P, Seligson AL, Sovak M (2006).
[5]. "Stability of resveratrol over time and in the various stages of grape transformation". Bertelli AA, Gozzini A, Stradi R, Stella S, Bertelli A (1998).
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Features:
All natural herbal extract from plant root.
We only use vegetarian capsules.
The oxygen in all bottles have been reduced to 0.02% or less, to eliminate oxidation.
Herbal powder is independently tested in a United States laboratory for safety and purity.
Herbal powder has been independently verified to activate the SIRT1 Gene as good as, or better than research grade Resveratrol.
Made in the USA.
Technical Specs:
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Extended Information:
Resveratrol Supplements - 1000mg (Capsules Starting at $95)Each Resveratrol Capsule = 500 Bottles of Wine.
Resveratrol 99% Powder - Each 1000mg capsule contains 990mg Trans-Resveratrol. The Resveratrol in this product comes from the Polygonum Cuspidatum plant.
Recommended Dosage:
1 or more capsules a day, but no more than one capsule per 100lbs of personal weight per day.
Why a 1000mg Capsule?
Because 100mg is fine for mice, but it is simply much too low for humans:
About
70% of the resveratrol dose given orally as a pill is absorbed;
nevertheless, oral bioavailability of resveratrol is low because it is
rapidly metabolized in intestines and liver into conjugated forms:
glucuronate and sulfonate.[1] Only trace amounts (below 5 ng/mL) of
unchanged resveratrol could be detected in the blood after 25 mg oral
dose.[1] Even when a very large dose of regular resveratrol (2.5 and 5
g) was given as uncoated pill, the concentration of resveratrol in
blood was only 2.4umol/L.[2]
[1]."High absorption but very low bioavailability of oral resveratrol in humans". Walle T, Hsieh F, DeLegge MH, Oatis JE, Walle UK (2004).
[2]. "Phase I Dose Escalation Pharmacokinetic Study in Healthy Volunteers of Resveratrol, a Potential Cancer Chemopreventive Agent". David J. Boocock, et al (2007).
What about the stability of Resveratrol?
Resveratrol
has been found to be stable. The trans- form can undergo isomerisation
to the cis- form when exposed to ultraviolet irradiation.[3]
Trans-resveratrol in the powder form was found to be stable under
"accelerated stability" conditions of 75% humidity and 40 degrees C in
the presence of air.[4] Resveratrol content also stayed stable in the
skins of grapes and pomace taken after fermentation and stored for a
long period.[5]
[3].
"Direct HPLC Analysis of cis- and trans-Resveratrol and Piceid Isomers
in Spanish Red Vitis vinifera Wines". Lamuela-Raventos, RM (1995).
[4]. "Resveratrol and its glycon piceid are stable polyphenols". Prokop J, Abrman P, Seligson AL, Sovak M (2006).
[5]. "Stability of resveratrol over time and in the various stages of grape transformation". Bertelli AA, Gozzini A, Stradi R, Stella S, Bertelli A (1998).
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